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Barbara J. Strupp

Adjunct Professor of Psychology
Professor of Nutritional Sciences

  • 217 Weill Hall
  • Cornell University
  • Ithaca NY 14853
    Office Hours:

Interests

In my lab, we are using rodent models to study human developmental cognitive disorders. This research is designed to identify the specific cognitive and affective processes that are affected and link these with underlying neural changes. The ultimate goals are to improve therapeutic intervention and elucidate basic brain-cognition relationships. Two projects, concerning prenatal cocaine exposure and early lead exposure, utilize rat models, whereas three other projects involve genetically manipulated mouse models of human disorders. These three projects deal with, respectively, mouse models of Down syndrome (the Ts65Dn mouse, which has a partial trisomy of chromosome 16),Fragile X syndrome (the fmr1 "knockout" mouse), and mice with a mutation in an enzyme involved in folate metabolism, to further investigate the role of folate alterations in neurogenesis and aging-related cognitive decline. We have recently discovered that perinatal supplementation with excess choline results in lasting cognitive benefits in the Down syndrome (DS) mouse model. This finding suggests that perinatal choline supplementation might significantly reduce the cognitive dysfunction seen in DS as well as reduce the risk of Alzheimer's Disease and age-related cognitive decline in the population at large. We are currently investigating the neural bases of this striking benefit.

Behavioral & Evolutionary Neuroscience

Selected Publications

  • Beaudin S, Stangle DE, Strawderman M, Levitsky, DA, and Strupp BJ. (2007) Succimer chelation normalizes emotion regulation in rats exposed to lead early in life: Evidence from an olfactory conditional discrimination task with periodic omission of an expected reward. Neurotox. Teratol 2007, 29: 188202 [Online 12 November 2006].

  • Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B. (2007) International Child Development Steering Group. Developmental potential in the first 5 years for children in developing countries. Lancet. 2007 Jan; 369(9555):60-70

  • Stangle DE, Smith D, Beaudin SA, Strawderman MS, Levitsky DA, and Strupp BJ. (2007) Succimer chelation improves cognition and arousal regulation in lead-exposed rats but produces lasting cognitive impairment in the absence of lead exposure. Environ Health Perspect. 2007 Feb;115(2):201-9. Epub 2006 Oct 30

  • Booze RM, Wallace DR, Silvers JM, Strupp BJ, and Mactutus CF. (2006) Prenatal cocaine alters alpha2 receptor expression in adolescent rats. BMC Neuroscience 2006, 7:33

  • Moon J, Beaudin AE, Crnic L, Levitsky, DA, Strupp BJ. (2006) Impairments in inhibitory control, arousal regulation and sustained attention in the fmr1 mouse model of Fragile X syndrome. Behavioral Neuroscience, 2006 Dec;120(6):1367-79

  • Strupp BJ & Beaudin S. Assessing the neurobehavioral effects of early toxicant exposure: A perspective from animal research. (2006) In: Bellinger D (ed.), Human Developmental Neurotoxicology, New York, NY: Taylor & Francis Group, 2006: 415-445

  • Driscoll LL; Carroll JC; Moon J-S; Crnic LS, Levitsky DA; Strupp BJ. (2004) Impaired Sustained attention and error-induced stereotypy in the aged Ts65Dn mouse, a mouse model of Down syndrome and Alzheimer disease. Behavioral Neuroscience, 2004, 118 (6): 11961205.

  • Gendle MH, Strawderman M, Mactutus CF, Levitsky DA, Booze RM, and Strupp BJ. (2004) Prenatal cocaine exposure does not alter spatial working memory in adult rats. Neurotoxicology and Teratology, 26(2): 319-329, 2004.

  • Gendle MH, White TL, Strawderman M, Mactutus CF, Booze RM, Levitsky DA, and Strupp BJ. (2004) Enduring Effects of Prenatal Cocaine Exposure on Selective Attention and Reactivity to Errors: Evidence from an Animal Model. Behavioral Neuroscience, 118(2): 290-297, 2004.

  • Stangle, DE., Strawderman M, Smith D., Kuypers M, & Strupp BJ. (2004) Repeated regimens of Succimer show different treatment efficacy in brain versus blood in a rodent model of childhood lead exposure, Environmental Health Perspectives, 112:302-308, 2004 (online, Oct. 31, 2003).

  • Gendle MH, Strawderman M, Mactutus CF, Levitsky DA, Booze RM, and Strupp BJ. (2003) Alterations in reactivity to errors and sustained attention in an animal model of prenatal cocaine exposure. Developmental Brain Research, 147, 2003, 85-96 (Special Edition on Drugs of Abuse, invited contribution).

  • Widholm JJ, Seo B-W, Strupp BJ, Seegal RF, Schantz SL. (2003) Effects of Perinatal Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) on Spatial and Visual Reversal Learning in Rats. Neurotoxicology and Teratology, 2003 Jul-Aug; 25(4): 459-71.

  • Bayer LE, Kakumanu S, Mactutus CF, Booze RM, Strupp BJ. (2002) Increased sensitivity to idazoxan in rats exposed to cocaine in utero: Evidence for enduring effects on catecholaminergic systems underlying attention. Behavioural Brain Research, 133(2):185-196, 2002

  • Morgan RE, Garavan H, Mactutus CF, Levitsky DA, Booze RM, Strupp BJ. (2002) Enduring effects of prenatal cocaine exposure on attentional control and reactivity to errors. Behavioral Neuroscience, 116(4):624-33, 2002.

  • Higley M., Hermer-Vazquez L., Levitsky D.A., Strupp BJ. (2001) Recovery of associative function following early amgydala lesions. Behavioral Neuroscience, 115, 154-164, 2001.

  • Morgan RE, Garavan H, Smith E, Driscoll LL, Levitsky DA, Strupp BJ. (2001) Enduring effects of early lead (Pb) exposure on sustained attention, response initiation, and reactivity to errors. Neurotoxicology and Teratology, 23(6): 519-532, 2001

  • Bayer LE, Brown A, Mactutus CF, Booze RM, Strupp BJ. (2000). Prenatal cocaine exposure increases sensitivity to the attentional effects of the dopamine D1 agonist SKF81297. J. Neurosci. 20(23):8902-8908, 2000.

  • Bushnell, P. J., Marrocco, R. T., Strupp, B. J., Sarter, M. F., Levin, E. D., & Warburton, D. M. (2000). Attention as a target of intoxication: Insights and methods from studies of drug abuse. Neurotoxicology and Teratology, 22(2), 487-502.

  • Garavan, H., Morgan, R. E., Hermer-Vazquez, L., Levitsky, D. A., & Strupp, B. J. (2000). Enduring effects of early lead exposure: Evidence for a specific deficit in associative ability. Neurotoxicology and Teratology, 22(2), 151-164.

  • Garavan H, Morgan RE, Mactutus CF, Levitsky DA, Booze RM, Strupp BJ. (2000) Prenatal cocaine exposure impairs selective attention: evidence from serial reversal and extradimensional shift tasks. Behavioral Neuroscience 114(4):725-738, 2000.

  • Morgan, R. E., Levitsky, D. A., & Strupp, B. J. (2000). Effects of chronic low-level lead exposure on learning and reaction time in a visual discrimination task. Neurotoxicology and Teratology, 22(3), 337-345.

  • Smith, D., Bayer, L. E., & Strupp, B. J. (1998). Efficacy of succimer chelation for reducing brain Pb levels in a rodent model. Environmental Research, 78, 168-176.

  • Strupp, B. J., Morgan, R. E., Garavan, H., Mactutus, C. F., & Booze, R. M. (1998). Prenatal cocaine exposure: An emerging cognitive profile. Neurotoxicology and Teratology, 20, 355.

  • Alber, S. A., & Strupp, B. J. (1996). An in-depth analysis of lead effects in a delayed spatial alternation task: Assessment of mnemonic effects, side bias and proactive interference. Neurotoxicology and Teratology, 18(1), 3-15.

  • Hilson, J., & Strupp, B. J. (1996). Analyses of response patterns clarify lead effects in olfactory reversal and extra-dimensional shift tasks: Assessment of inhibitory control, associative ability, and memory. Behavioral Neuroscience, 111(3), 532-542.

  • Strupp, B. J., & Diamond, A. (1996). Assessing cognitive function in animal models of mental retardation. Mental Retardation and Developmental Disabilities Research Reviews, 2(4), 216-226.

  • Bunsey, M. D., & Strupp, B. J. (1995). Specific effects of Idazoxan in a distraction task: Evidence that endogenous norepinephrine plays a role in selective attention. Behavioral Neuroscience, 109(5), 903-911.

  • Strupp, B. J., & Levitsky, D. A. (1995). Enduring cognitive effects of early malnutrition: A theoretical re-appraisal. Journal of Nutrition, 125, 2221S-2232S.

  • Strupp, B. J., Bunsey, M., Levitsky, D. A., & Hamberger, K. (1994). Deficient cumulative learning: An animal model of retarded cognitive development. Neurotoxicology and Teratology, 16(1), 71-79.

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updated on Thursday, Mar 19 2015 @ 3:54pm